Despite more than a year and a half of research, there are still many unknowns about how the virus that causes COVID-19 infects human cells. A deeper understanding could lead to new treatment approaches.
Pseudomonas bacteria use a kind of harpoon to attack nearby bacteria, injecting them with a toxin that targets a critical molecular machine called the transamidosome complex. Credit: Despoina Mavridou/University of Texas at Austin.
Antibiotic resistance, where disease-causing bacteria evolve resistance to drugs that usually kill them, is a rising problem globally, meaning new antibiotics need to be found. However, it is difficult for researchers to know which parts of bacterial cells to target with new drugs.
Jason McLellan, a faculty member in the Department of Molecular Biosciences, has been selected as the Texas Inventor of the Year for his role in biomedical research linked to the development of vaccines and treatments for COVID-19. The award is given annually by the State Bar of Texas's Intellectual Property Section in recognition of an individual whose invention "has significantly impacted the Texas economy."
Pairs of seedlings show the difference in growth patterns for plants living in 22°C (left one in each pair) versus 28°C (right). Pairs of seedlings are shown for each day, from 2 to 7 days.
When air temperatures rise, plants tend to grow differently: they grow taller, their roots grow deeper, they bloom earlier and pores in their leaves get fewer. By helping them stay cooler and retain more water, these changes might enable them to adapt to our rapidly warming world. But there's a big downside for us humans. When it's hotter, crop plants that we depend on tend to have a lower yield.
An analysis of blood plasma samples from people who recovered from SARS-CoV-2 infections shows that most of the antibodies circulating in the blood -- on average, about 84% -- target areas of the viral spike protein outside the receptor binding domain (RBD, green), including the N-terminal Domain (NTD, blue) and the S2 subunit (red, yellow). Illustration credit: University of Texas at Austin.
The most complete picture yet is coming into focus of how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection. In the journal Science, researchers at The University of Texas at Austin describe the finding, which represents good news for designing the next generation of vaccines to protect against variants of the virus or future emerging coronaviruses.
Drugs used to treat hepatitis C render remdesivir 10 times better at inhibiting the coronavirus in cell cultures, according to new study. Illustration credit: Jenna Luecke/University of Texas at Austin.
Remdesivir is currently the only antiviral drug approved in the U.S. for treating COVID-19 patients. In a paper published this week in Cell Reports, researchers from The University of Texas at Austin, Rensselaer Polytechnic Institute (RPI) and the Icahn School of Medicine at Mount Sinai showed that four drugs used to treat hepatitis C render remdesivir 10 times better at inhibiting the coronavirus in cell cultures.
Clinical trials of the COVID-19 vaccine candidate NDV-HXP-S, which includes a key protein developed at the University of Texas at Austin, began in Thailand in March 2021. Photo courtesy of Thailand’s Government Pharmaceutical Organization (GPO).
In a major boost to efforts to combat COVID-19 globally, a vaccine that recently entered human trials in Vietnam and Thailand, and is slated for a clinical study in Brazil, holds promise for affordable vaccine manufacturing in countries currently dependent on imported vaccines. The vaccine is the result of a partnership between The University of Texas at Austin, the Icahn School of Medicine at Mount Sinai in New York and global partners interested in advancing the supply of affordable vaccines to address the pandemic.
Gene editing with CRISPR enzymes inside living cells could become more effective and accurate after researchers at The University of Texas at Austin unveiled how inner workings can help or hinder the process.
The Welch Foundation today announced that Ilya J. Finkelstein, an associate professor of molecular biosciences at The University of Texas at Austin who has been researching the coronavirus and the gene-editing tool CRISPR, will receive the 2021 Norman Hackerman Award in Chemical Research. Having already made significant scientific contributions in chemistry and biochemistry, he is being recognized as a rising star in his field.
Four faculty members from the University of Texas at Austin's College of Natural Sciences have received 2021 Sloan Research Fellowships, which honor outstanding early-career scientists in eight fields.
Interior of a bin with polyethylene and mealworms. Photo courtesy of Emily Samson.
In search of a way to reduce the amount of plastic pollution an individual creates, a team of undergraduates in the UT Austin Inventors Program are exploring how mealworms, and the microbes in their guts, can naturally degrade household plastics.
Remdesivir is the only antiviral drug approved for use in the U.S. against COVID-19. Photo courtesy of Gilead.
More effective antiviral treatments could be on the way after research from The University of Texas at Austin sheds new light on the COVID-19 antiviral drug remdesivir, the only treatment of its kind currently approved in the U.S. for the coronavirus.
Jason McLellan (left) and Daniel Wrapp have been awarded the Golden Goose Award. Credit: Vivian Abagiu.
The world's largest multidisciplinary scientific society has announced that Jason McLellan, a University of Texas at Austin associate professor in the Department of Molecular Biosciences, and Daniel Wrapp, a graduate student fellow, were among seven winners of this year's Golden Goose Award. Supported by members of Congress from both parties and a coalition of businesses, universities and scientific societies since 2012, the prize this year went to scientists "whose federally funded research has had a significant impact for the response and treatment of COVID-19."
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