-
-
-
sbsung@austin.utexas.edu
Phone: 512-232-0867
Office Location
NMS 5.110
Postal Address
2506 SPEEDWAY
AUSTIN, TX 78712-
Seoul National University, Biology, BS (summa cum laude), 1996
Seoul National University, Biology, MS, 1998
University of Wisconsin in Madison, Biochemistry, PhD, 2004
University of Wisconsin in Madison, Biochemistry, Postdoc, 2004 ~ 2007
Research Summary:
Temperature and light induce epigenetic changes that trigger developmental transitions involving chromatin modifications, long noncoding RNAs (lncRNAs), and alterations in the three-dimensional structure of chromatin. The extensive knowledge of protein components, as well as lncRNA components, makes Arabidopsis a valuable model for studying the epigenetic mechanisms of gene regulation, with implications for gene regulation in all eukaryotes, including yeast, Drosophila, and humans. Moreover, the environmentally induced nature of developmental responses, such as the vernalization response and light response, offers a unique opportunity to investigate the impact of the environment on the epigenetic regulation of gene expression in developmental programs. We utilize this environmentally-induced epigenetic switch as a model system to explore chromatin remodeling in eukaryotes.
-
Publications:
Warm temperature-triggered developmental reprogramming requires VIL1-mediated, genome-wide H3K27me3 accumulation in Arabidopsis. Development. 2023 50(5). doi: 10.1242/dev.201343.
Highlighted in "Plants feel the heat via VIL1". Development, 150, 5, Pp. e150_e050
Zong W, J. Kim, Y. Bordiya, H. Qiao, S. Sung. 2022, ABA negatively regulates the Polycomb-mediated H3K27me3 through the PHD-finger protein, VIL1. New Phytol. 235(3):1057-1068.Kar S., Y. Bordiya, N. Rodriguez, J. Kim, E. C. Gardner, J. D. Gollihar, S. Sung*, A. D. Ellington*, 2022, Orthogonal control of gene expression in plants using synthetic promoters and CRISPR-based transcription factors, Plant Methods, 18(1):42.
Brightbill, C. M., S. Sung, 2022, Temperature-mediated regulation of flowering time in Arabidopsis thaliana, aBIOTECH, 3:78–84.
Kim J., S. Sung, 2021, Looping by RNA: Dynamic control of chromatin loop by long non-coding RNA in plants. Mol. Plant. 14(9):1430-1432.
Kim J., Y. Bordiya, P. K. Kathare, B. Zhao, W. Zong, E. Huq, S. Sung, 2021, Phytochrome B triggers light-dependent chromatin-remodeling through the PRC2-associated PHD finger protein, VIL1. Nature Plants, 7(9):1213-1219.
Zhao B, Xi Y, Kim J, Sung S., 2021, Chromatin architectural proteins regulate flowering time by precluding gene looping., Science Adv. eabg3097.
Zong W, Zhao B, Xi Y, Bordiya Y, Mun H, Cerda NA, Kim DH, Sung S., 2021, DEK domain-containing proteins control flowering time in Arabidopsis., New Phytol., 231:182-192
Wang W, Paik I, Kim J, Hou X, Sung S, Huq E., 2021, Direct phosphorylation of HY5 by SPA kinases to regulate photomorphogenesis in Arabidopsis., New Phytol., 230:2311-2326.
Xi Y., S. Park, D. Kim, E. Kim,S. Sung, 2020, Transcriptome and epigenome analyses of vernalization in Arabidopsis thaliana., Plant J., 103:1490-1502.
Chen C., D. Kim, H. Yun, Y. Lee, Y. Bordiya, B. Zhao, J. Kim, H. Kim, J. Min, Y. Lee, Y. Rim, H. Oh, H. Kim, S. Sung, J. Heo, 2020, Nuclear Import of the LIKE HETEROCHROMATIN PROTEIN1 is mediated by Importin-a 1, Importin-a 2, and Importin-a 3., Plant J., 103:1205-1214.
Kim ED, Y. Xiong, B.-H. Kang, S. Sung, 2019, Identification of long noncoding RNAs in the developing endosperm of Maize. Methods. in Mol. Biol., 1933:49-65.
Wang L., Y. Xi, S. Sung, H. Qiao, 2018, RNA-seq assistant: machine learning based methods to identify more transcriptional regulated genes. BMC Genomics, 19(1):546.
Kim D. H., Xi Y., and Sung S, 2017, Modular function of long noncoding RNA, COLDAIR, in the vernalization response. PLoS Genet, 13(7):e1006939.
Kim ED, Y Xiong, Y. Pyo, DH Kim, BH Kang, S. Sung, 2017, Spatio-temporal analysis of coding and long noncoding transcripts during maize endosperm development, Scientific Rep., 19;7(1):3838.
Kim D. H. and Sung S, 2017, Vernalization-triggered intragenic chromatin-loop formation by long noncoding RNAs. Developmental Cell, (16) 30916-9.
Kim DH, Sung S., 2017, Accelerated vernalization response by an altered PHD-finger protein in Arabidopsis. Plant Signal Behav. 12(5):e1308619.
Kim D. H. and Sung S, 2017, The binding specificity of PHD-finger domain of VIN3 moderates vernalization response. Plant Physiology, 173(2):1258-1268.
Zhang F, L. Wang, J.Y. Lim, T Kim, Y. Pyo, S. Sung, C. Shin, H. Qiao, 2016, Phosphorylation of CBP20 Links MicroRNA to Root Growth in the Ethylene Response. PLoS Genet 12(11):e1006437.
Sharma, N., R. Xin, D.-H. Kim, S. Sung, T Lange, and E. Huq, 2016, NO FLOWERING IN SHORT DAY (NFL) is a bHLH transcription factor that promotes flowering specifically under short-day in Arabidopsis, Development, 143(4):682-90.
Kim D. H. and Sung S, 2014, Polycomb-Mediated Gene Silencing in Arabidopsis thaliana. Mol Cells., 31;37(12):841-850.
Xiong, Y., Mei W., Kim E. D. , Mukherjee K., Hassanein H., Barbazuk W., Sung S., Kolaczkowski B., B. H. Kang, 2014, Adaptive expansion of the maize, BMC Plant Biol., 14(1):204.
Pyo, Y., S. Park, Y. Xi and S. Sung, 2014, Regulation of Flowering by Vernalisation in Arabidopsis. Advances in Botanical Research 72:29-61.
Kim D. H. and Sung S, 2014, Vernalization. Temperature and Plant Development (edited by K. A. Frankin & OP. A. Wigge), 79-95.
Jones, A. L. and S. Sung, 2014, Mechanisms underlying epigenetic regulation in Arabidopsis thaliana, Integr Comp Biol., 54(1) 61-7.
Kim, D. H. and S. Sung, 2014, Genetic and Epigenetics Mechanisms Underlying Vernalization, The Arabidopsis Book, 12: e0171.
Heo, J. B. , Y. S. Lee and S. Sung, 2013, Epigenetic regulation by long noncoding RNAs in plants. Chromosome Res., 21:685-93.
Kim, D. H. and S. Sung, 2013, Coordination of the vernalization response through a VIN3 and FLC gene family regulatory network in Arabidopsis. Plant Cell, 25(2):454-69.
Hyun, Y., H. Yun, K. Park, H. Ohr, O. Lee, D. H. Kim, S. Sung and Y. Choi, 2013, Stable inheritance of epigenetic histone modifications requires INCURVATA2, the catalytic subunit of Arabidopsis DNA polymerase [alpha], Development, 140(1):156-66.
Zografos B. R. and S. Sung, 2012, Vernalization-mediated chromatin changes, J. Exp. Bot., 63:4343-8.
Heo J. B., S. Sung and S. Assmann, 2012, A Ca2+-dependent GTPase, EXTRA-LARGE G-PROTEIN2 (XLG2), promotes activation of the DNA binding-protein RELATED TO VERNALIZATION1 (RTV1), leading to activation of floral integrator genes and early flowering in Arabidopsis. J. Biol. Chem., 287:8242-8253.
Kim D. H. and S. Sung, 2012, Environmentally coordinated epigenetic silencing of FLC by protein and long noncoding RNA components, Curr. Op. in Plant Biol., 15(1):51-6.
Kim E. D. and S. Sung, 2012, Long noncoding RNA: Unveiling hidden layer of gene regulatory networks in plants, Trends in Plant Sci. , 17(1):16-21.
Heo J. B. and S. Sung, 2011, Encoding memory of winter by noncoding RNAs., Epigenetics, 5:544-7.
Heo J. B. and S. Sung, 2011, Vernalization-mediated epigenetic silencing by a long intronic noncoding RNA, Science, 331: 76-9.
Kim D. H. and S. Sung, 2010, Role of VIN3-LIKE 2 in facultative photoperiodic flowering response in Arabidopsis, Plant Sig. Behav., 26(5):1672-3.
Kim D. H. and S. Sung, 2010, The Plant Homeo Domain finger protein, VIN3-LIKE 2, is necessary for photoperiod-mediated epigenetic regulation of the floral repressor, MAF5, Proc. Natl. Acad. Sci., 107(39): 17029-17034
Kim D. H., B.R. Zografos, and S. Sung, 2010, Mechanisms underlying vernalization-mediated VIN3 induction Plant Signal Behav., 26(5):1457-9.
Kim D. H., B.R. Zografos, and S. Sung, 2010, Vernalization-mediated VIN3 induction overcomes the LIKE-HETEROCHROMATIN PROTEIN 1/Polycomb Repression Complex 2 -mediated epigenetic repression. Plant Physiol., 154:949-957
Horvath D. P., S. Sung, D.-H. Kim, W. Chao, and J. V. Anderson, 2010, Characterization, expression and function of DORMANCY ASSOCIATED MADS-BOX genes from leafy spurge. Plant Mol. Bio., 73:169-79
Kim, D.-H., M. Doyle, S. Sung, and R. M. Amasino, 2009, VERNALIZATION: WINTER AND THE TIMING OF FLOWERING IN PLANTS. Annual Rev. Cell Dev. Biol., 25:277-299.
Schmitz R.*, S. Sung*, and R. M. Amasino, 2008, AtPRMT5-Mediated Symmetric Di-methylation of Arginine 3 of Histone 4 is Required for Maintenance of Vernalization-Induced Epigenetic Silencing of FLC in Winter-Annual Strains of Arabidopsis thaliana, Proc. Natl. Acad. Sci., 105:411-6. (* denotes equal contribution)
Sung S., R. Schmitz and R. M. Amasino, 2007, The Role of VIN3-LIKE Genes in Environmentally Induced Epigenetic Regulation of Flowering, Plant Signal Behav. 2(2):127-8.
Sung S., R. Schmitz and R. M. Amasino, 2006, A PHD finger protein involved in both the vernalization and photoperiod pathways in Arabidopsis., Genes Dev., 20:3244-8.
Sung S., and R. M. Amasino, 2006, Molecular genetic studies of the memory of winter, J. Exp. Bot., 57:3369-77.
Sung S., Y. He, T. W. Eshoo, Y. Tamada, L. Johnson, K. Nakahigashi, K. Goto, S. E. Jacobsen and R. M. Amasino, 2006, Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1, Nature Genet. 38:706-10
Sung, S. and R. M. Amasino, 2005, To remember winter: Towards a molecular understanding of vernalization, Annual Rev. Plant. Biol., 56:491-508.
Sung, S. and R. M. Amasino, 2004, Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3, Nature 427:159-164.
Sung, S. and R. M. Amasino, 2004, Vernalization and epigenetics: how plants remember winter, Curr. Op. in Plant Biol. 7:4-10.
Hall, A., R.M. Bastow, S. J. Davis, S Hanano, H. G. McWatters, V. Hibberd, M. R. Doyle, S. Sung, K. J. Halliday, R. M. Amasino and A. J. Millar, 2003, The TIME FOR COFFEE gene maintains the amplitude and timing of Arabidopsis circadian clocks, Plant Cell 15:2719-2729.
Schranz, M. E., P Quijada, S.-B. Sung, L. Lukens, R Amasino and T.C. Osborn, 2002, Characterization and effects of the replicated flowering time gene FLC in Brassica rapa, Genetics 162:1457-1468.
Doyle, M., S.-B. Sung and R Amasino, 2001, Plant Reproduction (edited by S. D. O'Neill and J. A. Roberts)-The genetic control of flowering time, Annual Plant Reviews 6:33-60
Lee, H., S. B. Sung, H. B. Kim and C. S. An, 2001, Sequence analysis and expression patterns of two nifA genes from EuIK1, Aust. J. Plant Physiol., 28:939-949.
Yoo, W.Y., S.B. Sung and C. S. An, 1999, Nucleotude sequences of the 2-oxoacid ferredoxin oxidoreductase and ferredoxin genes from Frankia strain EuIK1, a symbiont of Elaegnus umbellate root nodules, Can. J. Bot. 77:1279-1286.
-
