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Jamie Yelland
Visualizing the steps of eukaryotic ribosome assembly-
Education
B.A. Biochemistry, Oberlin College (2013)
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Advisors: Dr. Arlen Johnson, Dr. David Taylor
Interests: Ribosome biogenesis, structures of nascent ribosomes, ribosome quality control, structural biology
The ribosome is an exceptionally complex macromolecular machine, responsible for protein synthesis in all eukaryotic cells. Using yeast genetics, cryo-electron microscopy and other techniques, I study the mechanisms of ribosome assembly in our favorite model eukaryote, baker's yeast. In particular, I study a number of evolutionarily conserved proteins that build and test the catalytic center of the large ribosomal subunit. This center is the site of all protein synthesis, so its proper assembly is crucial for cellular function. My work is thus leading to a deeper understanding of how ribosome synthesis, an essential process for life, is monitored and controlled by the cell.
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Schepers, M. J., Yelland, J. N., Moran, N. A. & Taylor, D. W. Isolation of the Buchnera aphidicola flagellum basal body complexes from the Buchnera membrane. PLoS One 16, e0245710 (2021).
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(2022) Joshua E. Neimark Award, American Association for the Advancement of Science
(2018) Hamilton Seed Grant (Department of Molecular Biosciences, The University of Texas at Austin)
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(2022) A single 2'-O-methylation gates nuclear export of the ribosomal large subunit. Poster, AAAS Annual Meeting.
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Teaching Assistant
Foundations of Biochemistry (David Hoffman, BCH339F) - Fall 2018
Molecular Machines (Karen Browning, BCH339M) - Fall 2019, Fall 2020
Lectures
Cryo-Electron Microscopy (Karen Browning, BCH339M) - Fall 2020, Fall 2021
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